About the project

Our research, a contribution to the improvement of research done on regeneration of bone defects.

About the project

The surgical management of patients with bone defects as a result of tumors, cysts, malformations or traumatic injuries is a frequent problem in traumatology, maxillofacial surgery and implantology due to the complexity of the intervention and also its recovery.

The Problem

There is a great challenge to quickly recover the anatomy and functionality of damaged bone structures to improve the quality of life of the patient and return it as soon as possible to a normal life.

The “gold-standard” for a bone graft is the patient’s own bone (autograft), obtained from another region of his body. This procedure has limitations, due to the low availability of bone donor sites with large volumes and the morbidity added by the additional surgical procedure, which is often more aggressive than the repair procedure.

Thus, historically, multiple alternatives of bone grafts have been developed, such as human bones from banks or corpses, bones from other animal species or natural or synthetic allograft materials (alloplastic). In this sense, Hydroxyapatite, tricalcium phosphate and their combinations are a viable, practical and easily accessible alternative, even more so now that manufacturing technology allows the generation of particle material with optimized and precise shapes and sizes, which generates a fundamental competitive advantage. Recent research suggests that porosity and geometry give the substrate osteoinductive properties, with a positive effect on the osteoblast differentiation of adult mesenchymal cells deposited on the substrate.

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Our work

Our work aims to be an important contribution to biomaterials that play a fundamental role in bone regeneration.

GEODBONE is a spin-off as a result of the Research and Development of the Pontifical Catholic University of Chile (PUC).

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